The Effects of PVP(Fe(III)) Catalyst on Polymer Molecular Weight and Gene Delivery Via Biodegradable Cross-Linked Polyethylenimine
نویسندگان
چکیده
منابع مشابه
Alkyl cross-linked low molecular weight polypropyleneimine dendrimers as efficient gene delivery vectors
Objective(s): First, 10-bromodecanoic acid was covalently attached to all available surface primary amines of PPI G2 and G3 to increase their lipophilicity. In the subsequent step, PPIs were conjugated to the alkylcarboxylate groups of alkylcarboxylate-PPI derivatives to increase the number of surface primary amines. Physicochemical properties of modified PPIs were determined. Transfection expe...
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Polyethylenimine (PEI), especially PEI 25 kDa, has been widely studied for delivery of nucleic acid drugs both in vitro and in vivo. However, it lacks degradable linkages and is too toxic for therapeutic applications. Hence, low-molecular-weight PEI has been explored as an alternative to PEI 25 kDa. To reduce cytotoxicity and increase transfection efficiency, we designed and synthesized a novel...
متن کاملalkyl cross-linked low molecular weight polypropyleneimine dendrimers as efficient gene delivery vectors
objective(s): first, 10-bromodecanoic acid was covalently attached to all available surface primary amines of ppi g2 and g3 to increase their lipophilicity. in the subsequent step, ppis were conjugated to the alkylcarboxylate groups of alkylcarboxylate-ppi derivatives to increase the number of surface primary amines. physicochemical properties of modified ppis were determined. transfection expe...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2011
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-011-0576-5